HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60796Generated: October 29, 2026
2-Chlorobenzoxazole → HCID 131737124, compound
https://huagongshe.com/reaction/60796
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzoxazole | HCID 11986 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone | HCID 117728006 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131737124 | HCID 131737124 | — |
Reaction Steps
A mixture of (2-(aminomethyl)-3-methylpiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone, 2-chlorobenzoxazole, and DIPEA in CH2Cl2 was stirred at 60° C. overnight. The reaction mixture was concentrated in vacuo to leave a near colorless solid. This solid was triturated with Et2O/hexanes to leave the title compound as a colorless solid homogeneous by HPLC analysis. MS (ESI) 447.03 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09440982B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-b0643335b6dd46abacecc9204d182444 |
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| Source note | uspto-grants-2016_09 |
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