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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 608001Generated: October 31, 2026

4-Chloroanisole → 4-Methoxybiphenyl

https://huagongshe.com/reaction/608001

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanisoleHCID 12167—
ReactantPhenylboronic AcidHCID 66827—
ReagentWaterHCID 962—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystBis(1,5-cyclooctadiene)nickelHCID 6433264—
CatalystDi-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-(1,1'-biphenyl)-2-yl)phosphineHCID 44233348—
Solvent1,4-DioxaneHCID 31275—
Product4-MethoxybiphenylHCID 119432%

Reaction Conditions

Temperature60 °C

Reaction Steps

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

Provenance & Evidence

DOI10.26434/chemrxiv.14388557.v1
Source datasetNi-catalyzed Suzuki Miyaura cross-coupling
ORD IDord-073d8c41026c42d2bfd42f9a249cd7a8
Source noteNi-catalyzed Suzuki Miyaura cross-coupling