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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 608034Generated: October 30, 2026

4-Chloroanisole → 4-Methoxybiphenyl

https://huagongshe.com/reaction/608034

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanisoleHCID 12167—
ReactantPhenylboronic AcidHCID 66827—
ReagentWaterHCID 962—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystTris(2-methylpropyl)phosphineHCID 107228—
CatalystBis(1,5-cyclooctadiene)nickelHCID 6433264—
Solvent1,4-DioxaneHCID 31275—
Product4-MethoxybiphenylHCID 119430%

Reaction Conditions

Temperature60 °C

Reaction Steps

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

Provenance & Evidence

DOI10.26434/chemrxiv.14388557.v1
Source datasetNi-catalyzed Suzuki Miyaura cross-coupling
ORD IDord-e3ff933a309b46bc84ef98c1fc3d02b7
Source noteNi-catalyzed Suzuki Miyaura cross-coupling