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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 608056Generated: October 30, 2026

4-Chloroanisole → 4-Methoxybiphenyl

https://huagongshe.com/reaction/608056

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanisoleHCID 12167—
ReactantPhenylboronic AcidHCID 66827—
ReagentWaterHCID 962—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystBis(1,5-cyclooctadiene)nickelHCID 6433264—
CatalystBis{4-[3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl]phenyl}(phenyl)phosphaneHCID 10653392—
Solvent1,4-DioxaneHCID 31275—
Product4-MethoxybiphenylHCID 119436%

Reaction Conditions

Temperature60 °C

Reaction Steps

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

Provenance & Evidence

DOI10.26434/chemrxiv.14388557.v1
Source datasetNi-catalyzed Suzuki Miyaura cross-coupling
ORD IDord-d7c24ebaf84d4375a809915a9ab6295d
Source noteNi-catalyzed Suzuki Miyaura cross-coupling