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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 608058Generated: November 2, 2026

4-Chloroanisole → 4-Methoxybiphenyl

https://huagongshe.com/reaction/608058

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanisoleHCID 12167—
ReactantPhenylboronic AcidHCID 66827—
ReagentWaterHCID 962—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystBis(1,5-cyclooctadiene)nickelHCID 6433264—
Catalyst2-[Bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl]benzaldehydeHCID 71310909—
Solvent1,4-DioxaneHCID 31275—
Product4-MethoxybiphenylHCID 119431%

Reaction Conditions

Temperature60 °C

Reaction Steps

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

Provenance & Evidence

DOI10.26434/chemrxiv.14388557.v1
Source datasetNi-catalyzed Suzuki Miyaura cross-coupling
ORD IDord-930716ce15894fb5aa896a537096aea3
Source noteNi-catalyzed Suzuki Miyaura cross-coupling