2-Methyl-6-(2-phenoxyethyl)pyridine → 2-Methyl-6-(2-phenoxyethyl)piperidine

HRID 60808Notes

Reaction equation

HRID 60808 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1>CO>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:3]1

Participants

3

Reactant 1

HCID 897395212-Methyl-6-(2-phenoxyethyl)pyridine

Product 1

HCID 897396142-Methyl-6-(2-phenoxyethyl)piperidine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Methyl-6-(2-phenoxyethyl)pyridine (0.19 mmol, 0.04 g) and Adam Catalyst (0.09 mmol, 0.02 g) in MeOH was stirred at rt under a hydrogen balloon overnight. The reaction mixture was filtered through diatomaceous earth and concentrated in vacuo to provide the desired product 2-methyl-6-(2-phenoxyethyl)piperidine in 30% conversion. This crude residue was used in the next step without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through diatomaceous earth
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f669ff95ddd44db093076eb130fdbb5f
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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