(4-(Cyclopentylcarbamoyl)phenyl)boronic acid → Biphenyl

HRID 608101ノート

反応式

HRID 608101 の反応式
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21.O=C(NC1CCCC1)c1ccc(B(O)O)cc1.O=P(O)(O)O.[K]>CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1[PH](C1CCCCC1)(C1CCCCC1)[Pd]1([O]S(C)(=O)=O)[NH]c2ccccc2-c2cccc[c]21.CS(C)=O.O>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(-c3ccc(C(=O)NC4CCCC4)cc3)c(C)cc21

参加物

9

反応物 2

HCID 2773358(4-(Cyclopentylcarbamoyl)phenyl)boronic acidHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

生成物 3

HCID 7095BiphenylHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylateHCID 178474758HCID 178474758、化合物

試薬・触媒・溶媒 4

HCID 178458464HCID 178458464、化合物触媒HCID 679Dimethyl Sulfoxide溶媒3 回HCID 962Water溶媒2 回HCID 16218557Phosphoric acid (potassium)その他

後処理

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

出典と根拠

ORDレコード
ord-bb724695efc742f8807735232dd22f9f
出典データセット
Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
元リンク
出典を表示

反応ノート

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