HRID60813

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID66582

8-Quinolinecarboxylic acid

C10H7NO2

结构：COC1=CN(C(=O)c2ccccc2-c2ccccc2)C(CNC(=O)c2cccc3cccnc23)CC1

HCID89740834

未命名化合物

PRODUCTS

生成物

结构：O=C1CCC(CNC(=O)c2cccc3cccnc23)N(C(=O)c2ccccc2-c2ccccc2)C1

HCID89739334

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide was prepared according general procedure A using quinoline-8-carboxylic acid and N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide which was synthesized from the product from Part VI above, following ketal cleavage using TFA and CH2Cl2. MS (ESI) 464 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79d459c41a05423997f37c19c5489e52
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09440982B2
来源说明: uspto-grants-2016_09

反应 SMILES

N1C2C(=CC=CC=2C(O)=O)C=CC=1.[C:14]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[C:15]([C:20]([N:22]2[CH:27]=[C:26]([O:28]C)[CH2:25][CH2:24][CH:23]2[CH2:30][NH:31][C:32]([C:34]2[CH:35]=[CH:36][CH:37]=[C:38]3[C:43]=2[N:42]=[CH:41][CH:40]=[CH:39]3)=[O:33])=[O:21])=[CH:16][CH:17]=[CH:18][CH:19]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:14]1([C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)[C:15]([C:20]([N:22]2[CH2:27][C:26](=[O:28])[CH2:25][CH2:24][CH:23]2[CH2:30][NH:31][C:32]([C:34]2[CH:35]=[CH:36][CH:37]=[C:38]3[C:43]=2[N:42]=[CH:41][CH:40]=[CH:39]3)=[O:33])=[O:21])=[CH:16][CH:17]=[CH:18][CH:19]=1