HRID60816

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21863450

未命名化合物

结构：Cc1nc(-c2ccccc2)c(C(=O)N2CC(=O)CCC2CNC(=O)c2cccc3cccnc23)s1

HCID89739420

未命名化合物

PRODUCTS

生成物

HCID71715162

未命名化合物

HCID89739420

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from the product of Part III above using TFA/CH2Cl2. MS (ESI) 485 (M+H). N-((5-hydroxy-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide was prepared according to general procedure K using N-((1-(2-methyl-4-phenylthiazole-5-carbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide. MS (ESI) 487 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f8daaa81824e4c60a922dab9a23ae83e
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09440982B2
来源说明: uspto-grants-2016_09

反应 SMILES

C(O)(C(F)(F)F)=O.C(Cl)Cl.[CH3:11][C:12]1[S:13][C:14]([C:23]([N:25]2[CH2:30][C:29](=[O:31])[CH2:28][CH2:27][CH:26]2[CH2:32][NH:33][C:34]([C:36]2[CH:37]=[CH:38][CH:39]=[C:40]3[C:45]=2[N:44]=[CH:43][CH:42]=[CH:41]3)=[O:35])=[O:24])=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1>>[CH3:11][C:12]1[S:13][C:14]([C:23]([N:25]2[CH2:30][C:29](=[O:31])[CH2:28][CH2:27][CH:26]2[CH2:32][NH:33][C:34]([C:36]2[CH:37]=[CH:38][CH:39]=[C:40]3[C:45]=2[N:44]=[CH:43][CH:42]=[CH:41]3)=[O:35])=[O:24])=[C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:16]=1.[OH:31][CH:29]1[CH2:30][N:25]([C:23]([C:14]2[S:13][C:12]([CH3:11])=[N:16][C:15]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:24])[CH:26]([CH2:32][NH:33][C:34]([C:36]2[CH:37]=[CH:38][CH:39]=[C:40]3[C:45]=2[N:44]=[CH:43][CH:42]=[CH:41]3)=[O:35])[CH2:27][CH2:28]1