反应详情

To a stirred solution of rac-cis-(2-(hydroxymethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone in DCM was added Dess-Martin periodinane (1.5 eq) and stirred at rt for 4 h. The reaction mixture was transferred to a seperatory funnel, diluted with more DCM, water and the layers were separated. The organic layer was washed with brine, dried (MgSO4), and concentrated in vacuo to give a crude residue which was purified by chromatography on silica gel (EtOAc/hex) to afford the title compound. MS (ESI) 347.1 (M+H).

1. customThe reaction mixture was transferred to a seperatory funnel
2. customthe layers were separated
3. washThe organic layer was washed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. customto give a crude residue which
7. customwas purified by chromatography on silica gel (EtOAc/hex)