HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl 2-acetylhexahydrocyclopenta[c]pyrrole-1,1(2H)-dicarboxylate | HCID 86587089 | — |
| Product | Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrobromide | HCID 117727800 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A solution of the rac-diethyl 2-acetylhexahydrocyclopenta[c]pyrrole-1,1(2H)-dicarboxylate prepared above in 48% aqueous HBr and AcOH (4:1) was heated at 120° C. for 16 h. The reaction mixture was cooled, concentrated in vacuo and lyophilized to yield the title compound. MS (ESI) 156 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440982B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-03dbab428d564c579c1a7d499dae9b94 |
| Source note | uspto-grants-2016_09 |