HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60864Generated: October 29, 2026
2-Chlorobenzoxazole → HCID 117727875, compound
https://huagongshe.com/reaction/60864
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzoxazole | HCID 11986 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1-(Aminomethyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 77286974 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 117727875 | HCID 117727875 | — |
Reaction Steps
A mixture of (1-(aminomethyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 2-chlorobenzoxazole, and DIPEA in ACN was stirred at 60° C. overnight. The reaction mixture was concentrated in vacuo. The crude reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound. MS (ESI) 477.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09440982B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-5007437300f34955b6af2ca37693c466 |
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| Source note | uspto-grants-2016_09 |
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