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HRID 60873作成日：2026年10月25日

5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid → rac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

https://huagongshe.com/reaction/60873

反応式

関与物質

役割名称HCID仕込み量
反応物5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 53260165—
反応物rac-cis-N-((3-Methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amineHCID 131737152—
生成物rac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanoneHCID 131737153—

反応手順

The title compound was synthesized following the same general protocol as described in Example 11 using 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid and rac-cis-N-((3-methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine. ESI-MS (m/z): 459, [M+1]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-4580950b5f2b428bab0c5ad71b7f24bd
出典メモuspto-grants-2016_09