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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60876Generated: October 25, 2026

2-Phenoxybenzoic acid → rac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl) (2-phenoxyphenyl)methanone

https://huagongshe.com/reaction/60876

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenoxybenzoic acidHCID 75237—
Reactantrac-cis-N-((3-Methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amineHCID 131737152—
Productrac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl) (2-phenoxyphenyl)methanoneHCID 131737156—

Reaction Steps

The title compound was synthesized following the same general protocol as described in Example 11 using 2-phenoxybenzoic acid and rac-cis-N-((3-methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine. ESI-MS (m/z): 470, [M+1]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-218977b2224e44238add87319fa1d837
Source noteuspto-grants-2016_09