2-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-methylbenzoic acid → (2-(3,5-Dimethylisoxazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

HRID 60904Notes

Reaction equation

HRID 60904 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:8]=2[C:9]([OH:11])=O)=[C:5]([CH3:17])[O:4][N:3]=1.[CH3:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][NH:21][C@@H:20]1[CH2:25][NH:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][N:28]=1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:8]=2[C:9]([N:21]2[CH2:22][CH2:23][CH2:24][C@@H:19]([CH3:18])[C@H:20]2[CH2:25][NH:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:29][N:28]=2)=[O:11])=[C:5]([CH3:17])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 532250212-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-methylbenzoic acidHCID 89739447N-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine

Product 1

HCID 117727827(2-(3,5-Dimethylisoxazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

Procedure

The title compound was prepared following the same general protocol as described for Example A1, using 2-(3,5-dimethylisoxazol-4-yl)-5-methylbenzoic acid and N-(((2S,3R)-3-methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine. ESI-MS (m/z): 487 [M+1]+.

Sources & evidence

ORD record
ord-2d7b1e587c4c418fb474701ae69c01d6
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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