Methyl iodide → HCID 178503973, compound

HRID 609572Notes

Reaction equation

HRID 609572 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([NH2:11])=[S:10].CI.[CH2:14]1CCCCC1>CC(C)=O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[NH:11])[S:10][CH3:14]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8078CyclohexaneHCID 2737500(2-Fluorophenyl)thiourea

Product 1

HCID 178503973HCID 178503973, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a stirred solution of 3.0 g (0.017 mol) of N-(2-fluorophenyl)thiourea in 75 ml of acetone was added an excess of methyl iodide. The reaction was allowed to stir over night. To the solution was then added 20 ml of cyclohexane; a white solid crystallized and was collected by filtration to yield 4.3 g of N-(2-fluorophenyl)-S-methylisothiourea.

Workup

  1. customa white solid crystallized
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-bd303794242f40028971177bc69def0d
Source dataset
uspto-grants-1999_12
Patent number
US05998399

Reaction notes

Loading…