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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 609588Generated: October 26, 2026

1H-Indole-3-carbonyl chloride → Quinolizidin-2-ylmethylindole-3-carboxylate

https://huagongshe.com/reaction/609588

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indole-3-carbonyl chlorideHCID 12380278—
ReactantOctahydro-2H-quinolizine-2-methanolHCID 70077295—
ProductQuinolizidin-2-ylmethylindole-3-carboxylateHCID 131719520—

Reaction Steps

eq-2-Hydroxymethylquinolizidine (N. J. Leonard et al., J. Org. Chem., 1957, 22, 1445) was reacted with indole-3-carboxylic acid chloride using the method described in Example 1 a to afford eq-quinolizidin-2-ylmethyl 1-H-indole-3-carboxylate mp 154-157° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05998409
Source datasetuspto-grants-1999_12
ORD IDord-8e3a402399f0436e9efede74d56438a7
Source noteuspto-grants-1999_12