2-(2-Methoxypyrimidin-5-yl)-5-methylbenzoic acid → ((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(2-methoxypyrimidin-5-yl)-5-methylphenyl)methanone

HRID 60960ノート

反応式

HRID 60960 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:10]=2[C:11]([OH:13])=O)=[CH:5][N:4]=1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]2[O:27][C:26]([NH:28][CH2:29][C@@H:30]3[C@H:35]([CH3:36])[CH2:34][CH2:33][CH2:32][NH:31]3)=[N:25][C:24]=2[CH:37]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]2[O:27][C:26]([NH:28][CH2:29][C@@H:30]3[C@H:35]([CH3:36])[CH2:34][CH2:33][CH2:32][N:31]3[C:11]([C:10]3[CH:14]=[C:15]([CH3:18])[CH:16]=[CH:17][C:9]=3[C:6]3[CH:7]=[N:8][C:3]([O:2][CH3:1])=[N:4][CH:5]=3)=[O:13])=[N:25][C:24]=2[CH:37]=1

参加物

3

反応物 2

HCID 1127475912-(2-Methoxypyrimidin-5-yl)-5-methylbenzoic acidHCID 1177280155-Chloro-N-(((2S,3R)-3-methylpiperidin-2-yl)methyl)benzo[d]oxazol-2-amine

生成物 1

HCID 117727762((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(2-methoxypyrimidin-5-yl)-5-methylphenyl)methanone

実験手順

The title compound was prepared following the same general protocol as described in Example A1, using 2-(2-methoxypyrimidin-5-yl)-5-methylbenzoic acid and 5-chloro-N-(((2S,3R)-3-methylpiperidin-2-yl)methyl)benzo[d]oxazol-2-amine. ESI-MS (m/z): 506 [M+1]+.

出典と根拠

ORDレコード
ord-8f59dbcd3c6a4eb0a47e209039d63291
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

反応ノート

読み込み中…