1H-Indole-3-carbonyl chloride → 1H-indole-3-carboxamide

HRID 609601Notes

Reaction equation

HRID 609601 reaction equation
[CH2:1]1[CH:10]2[N:5]([CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:4]C[CH:2]1[CH2:11][NH2:12].N1C2C(=CC=CC=2)C(C(Cl)=[O:23])=C1>>[NH:5]1[C:10]2[C:1](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:2]([C:11]([NH2:12])=[O:23])=[CH:4]1

Participants

3

Reactant 2

HCID 123802781H-Indole-3-carbonyl chlorideHCID 82413010Quinolizidin-2-ylmethylamine

Product 1

HCID 21925421H-indole-3-carboxamideYield 55%

Procedure

eq-Quinolizidin-2-ylmethylamine (D12) was reacted with indole-3-carboxylic acid chloride using the method of Description 1b) to afford N-(eq-quinolizidin-2-ylmethyl) indole-3-carboxamide as a white solid (55%).

Sources & evidence

ORD record
ord-adbe2f331afb48e09d8aaccac563c705
Source dataset
uspto-grants-1999_12
Patent number
US05998409

Reaction notes

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