Hydrochloric Acid → HCID 19599426, compound

Participants

Reaction Steps

A stirred solution of methyl 6,7-dihydropyrido[1,2-a]indole-10-carboxylate (T. Teitei and L. K. Dalton, Australian J. Chem 1969, 22, 997) (1.0 g, 0.0044 mole) in methanol (40 ml) was treated with a solution of potassium hydroxide (3.0 g, 0.054 mole) in water (50 ml) and heated under reflux for 3 h. The solution was allowed to cool, then acidified with HCl acid and extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated under vacuum to leave the title compound (D8) as a yellow solid (600 mg, 64%).

Provenance & Evidence