HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+-)-3-Quinuclidinol → 1-azabicyclo[2.2.2]octan-3-yl N-(4-bromophenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+-)-3-Quinuclidinol | HCID 15381 | — |
| Reactant | 4-Bromophenyl isocyanate | HCID 75609 | — |
| Product | 1-azabicyclo[2.2.2]octan-3-yl N-(4-bromophenyl)carbamate | HCID 10019186 | 60% |
Reaction Steps
3-Quinuclidinol and 4-bromophenyl isocyanate were used. Filtration of the precipitated solid from the cooled reaction mixture afforded the title compound (60%) as a white solid: mp 217.5-219.5° C.; FAB LRMS m /z (relative intensity, %)328(16), 327 ([MH+ with Br81 ], 100), 326(16), 325 ([MH+ with Br79 ], 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998429 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-8db0203a650d49ee8e10395f06ef2745 |
| Source note | uspto-grants-1999_12 |