反应详情

In the same way as that described in Example 4, Step 1, using tert-butyl-N-(2-aminoethyl)carbamate (1.6 g, 10 mmol), 2-phenylpropionaldehyde (1.32 mL, 10 mmol), MeOH (100 mL), acetic acid (1.72 mL, 30 mmol) and sodium cyanoborohydride (1.26 g, 20 mmol). The crude residue was chromatographed on silica gel, eluting with CH2Cl2 :MeOH (90:10), to give the amine (1.56 g, 56%) as a colourless oil. 1H NMR (250 MHz, CDCl3) δ1.26 (3H, d, J=6.9 Hz), 1.42 (9H, s), 2.70-2.81 (4H, m), 2.90-3.00 (1H, m), 3.14-3.24 (2H, m), 4.89 (1H, br s), 7.19-7.35 (5H, m).

1. customThe crude residue was chromatographed on silica gel
2. washeluting with CH2Cl2 :MeOH (90:10)