Dichloromethane → HCID 19599744, compound

Participants

Reaction Steps

In the same way as that described in Example 2, Step 3, using 2-[(bromoacetyl)(2-phenylpropyl)amino]ethyl carbamic acid tert-butyl ester (1.64 g, 4.11 mmol), trifluoroacetic acid (4 mL) and CH2Cl2 (40 mL), followed by K2CO3 (1.1 g, 8.2 mmol) and EtOH (100 mL). The piperazinone (668 mg, 75%) was isolated as a colourless oil. 1H NMR (250 MHz, CDCl3) δ1.28 (3H, d, J=6.8 Hz), 2.72-2.93 (3H, m), 3.04-3.26 (3H, m), 3.28 (1H, d, J=17.3 Hz), 3.52 (1H, d, J=17.3 Hz), 3.85-3.93 (1H, m), 7.19-7.35 (5H, m).

Provenance & Evidence