(1-Bromoethyl)benzene → HCID 19599742, compound

Participants

Reaction Steps

In the same way as that described in Example 1, Step 1, using Intermediate 1 (500 mg, 2.5 mmol), sodium hydride (110 mg of a 60% dispersion in mineral oil, 2.8 mmol), (1-bromoethyl)benzene (0.44 mL, 3.25 mmol) and DMF (12 mL). The title piperazinone (677 mg, 89%) was isolated as a colourless oil, which solidified on standing at 0° C. mp. 62-64° C. 1H NMR (250 MHz, CDCl3) δ1.40 (9H, s), 1.53 (3H, d, J=7.2 Hz), 2.80-2.90 (1H, m), 3.14-3.36 (2H, m), 3.56-3.71 (1H, m), 4.07 (1H, d, J=18.2 Hz), 4.22 (1H, d, 18.2 Hz), 6.08 (1H, q, J=7.2 Hz), 7.28-7.39 (5H, m).

Provenance & Evidence