Trifluoroacetic acid → HCID 19599733, compound

Participants

Reaction Steps

Prepared in the same manner as that described in Example 5, Step 2, using 1-(1-phenylethyl)-4-(tert-butyloxycarbonyl)piperazin-2-one (673 mg, 2.2 mmol), trifluoroacetic acid (4 mL) and CH2Cl2 (40 mL). The crude product was chromatographed on silica gel, eluting with CH2Cl2 :MeOH (90:10), to afford the amine (307 mg, 68%) as a colourless oil. 1H NMR (250 MHz, CDCl3) δ1.53 (3H, d, J=7.2 Hz), 2.75-2.94 (2H, m), 2.98-3.07 (1H, m), 3.12-3.21 (1H, m), 3.62 (2H, s), 6.13 (1H, q, J=7.2 Hz), 7.24-7.39 (5H, m).

Provenance & Evidence