Potassium Hydroxide → HCID 19600470, compound

Participants

Reaction Steps

To 5-(2,3-dihydropyran-2-yl)-3-[2-(N,N-dimethylamino)ethyl]-1-benzoylindole (Example 18e, 0.048, 0.129 mmol) was added a 5% solution of KOH in MeOH (5 mL) followed by methanol (5 mL). The solution was heated at reflux for 3 hours. At this time, the solution was allowed to cool, and was filtered and concentrated by reduced pressure. The crude product was purified by column chromatography [7% NH3 (2M in MeOH) in CH2Cl2 ] to yield the title compound as a yellow oil (19.6 mg, 56%); HRMS-FAB+ for C17H22N2O: calc. MH+ :271.1810; found MH+ :271.1826.

Provenance & Evidence