5-Bromoindole → 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

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Reaction Steps

5-Bromoindole (4.31 g, 22 mmol), 1-methyl4-piperidone (2.46 mL, 20 mmol) and pyrrolidine (17 mL, 200 mmol) were mixed in ethanol (30 mL) and refluxed for 72 hours. The mixture was cooled to room temperature and the resulting solid, collected by filtration, washed with methanol and dried to provide as 5-bromo-3-(1,2,3,6-tetrahydro-1-methyl4-pyridinyl)-1H-indole white solid (4.40 g, 76%). mp>230° C. dec.

Provenance & Evidence