HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(1-(4-Fluoro-benzyl)-1h-benzoimidazole-2-carbonyl)-piperidine trifluoroacetic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-(t-butoxycarbonyl)-4-(1-(4-fluoro-benzyl)-1H-benzoimidazole-2-carbonyl)-piperidine | HCID 18333339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(1-(4-Fluoro-benzyl)-1h-benzoimidazole-2-carbonyl)-piperidine trifluoroacetic acid salt | HCID 70101665 | — |
Reaction Steps
Cool the 1-(t-butoxycarbonyl)-4-(1-(4-fluoro-benzyl)-1H-benzoimidazole-2-carbonyl)-piperidine in an ice bath. Add trifluoroacetic acid and mix. After 15 minutes, add diethyl ether to give a residue. Collect the residue by filtration and dry under vacuum. Recrystallize from ethanol/ether and dry resulting solid under vacuum to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998439 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-2f5182fa917a4fd288473f8c3dad2124 |
| Source note | uspto-grants-1999_12 |