5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid → rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

HRID 60992Notes

Reaction equation

HRID 60992 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1N=C(C)S[C:16]=1[C:17]1[CH:22]=[CH:21][C:20](F)=C[CH:18]=1)=[O:11].CC1C=CC([N:35]2[N:39]=[CH:38][CH:37]=[N:36]2)=C(C=1)C(O)=O>>[NH2:1][CH2:2][C@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:16]=[C:17]([CH3:18])[CH:22]=[CH:21][C:20]=1[N:35]1[N:39]=[CH:38][CH:37]=[N:36]1)=[O:11]

Participants

3

Reactant 2

HCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 131737142rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Product 1

HCID 131737162rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for rac-trans-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone in Example A65 using 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI) 314 (M+H).

Sources & evidence

ORD record
ord-2efa83bb97d34160946d1bc71ff9d6e7
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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