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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60993Generated: October 26, 2026

Acetamidomalonic acid diethyl ester → Diethyl 2-acetylhexahydrocyclopenta[c]pyrrole-1,1(2H)-dicarboxylate

https://huagongshe.com/reaction/60993

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetamidomalonic acid diethyl esterHCID 14041—
Reactant1-Cyclopentene-1-carboxaldehydeHCID 138672—
ProductDiethyl 2-acetylhexahydrocyclopenta[c]pyrrole-1,1(2H)-dicarboxylateHCID 86587089—

Reaction Steps

The title compound was prepared from cyclopenten-1-aldehyde (1 equiv.) and diethyl 2-acetamidomalonate using the procedure by Chung et al (J. Org. Chem. 1990, 55, 270). MS (ESI) 298 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-193f85cdd1844bcc9bcae5df18637b75
Source noteuspto-grants-2016_09