Bromine → 2-bromo-1-(2,5-difluorophenyl)propan-1-one

HRID 610039Notes

Reaction equation

HRID 610039 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br>C(OCC)C>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 1201372',5'-Difluoropropiophenone

Product 1

HCID 221113352-bromo-1-(2,5-difluorophenyl)propan-1-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 2',5'-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The either layer was concentrated under reduced pressure to provide the title compound.

Workup

  1. additionTo this reaction mixture was added ice
  2. customthe diethyl ether layer was separated
  3. washby washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order
  4. dry with materialdried over anhydrous magnesium sulfate (MgSO4)
  5. concentrationThe either layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3a2af378552a4d619a718a80242d055f
Source dataset
uspto-grants-1999_12
Patent number
US05998459

Reaction notes

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