Morpholine → 3-Amino-3-morpholinoacrylonitrile

HRID 610040Notes

Reaction equation

HRID 610040 reaction equation
[C:1]([CH2:3][C:4](=[NH:8])OCC)#[N:2].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>C(O)C>[NH2:8][C:4]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[CH:3][C:1]#[N:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 256188Ethyl 2-cyanoethanecarboximidate

Product 1

HCID 27636313-Amino-3-morpholinoacrylonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In anhydrous ethanol (10 ml) was dissolved ethyl 2-cyanoacetimidate (1.0 g), followed by addition of morpholine (0.78 g). The mixture was stirred at room temperature for 4 hours, and the separated crystals were collected by filtration. This crystal crop was used as it was in the next reaction.

Workup

  1. filtrationthe separated crystals were collected by filtration
  2. customwas in the next reaction

Sources & evidence

ORD record
ord-007f37c576bd446793605b8aa1a181ca
Source dataset
uspto-grants-1999_12
Patent number
US05998459

Reaction notes

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