HCID 15870568, compound → HCID 15870567, compound

Participants

Reaction Steps

5-Vinyl-3-(2-pyrrolidinylethyl)-1H-indole (Example 10c, 8.0 mg, 0.033 mmol) in ethyl acetate (3 mL) containing a spatula tip of Pd/C (10%) was stirred at room temperature under an atmosphere of hydrogen for 2.5 h. Filtration through celite using 10% 2M methanolic ammonia in dichloromethane and evaporation of the solvent in vacuo. A final filtration through silica gel using 10% 2M methanolic ammonia in dichloromethane yielded 5-ethyl-3-(2-pyrrolidinylethyl) -1H-indole (4.5 mg, 56%).

Provenance & Evidence