Perchloric Acid → 1,3-Dihydro-1-(2,2,2-trifluoroethyl)-2H-indol-2-one

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Reaction Steps

A mixture of 1-(2,2,2-trifluoro-ethyl)-1H-indole-2,3-dione (9.2 g, 40 mmol) and 10% palladium on carbon (2.4 g) in acetic acid (100 mL) and 70% perchloric acid (6.4 mL, 80 mmol) was hydrogenated in a Parr apparatus for 22 hours. The mixture was filtered through diatomaceous earth, diluted with water (1.5 L) and the precipitate was collected and dried. mp 155-162° C. Yield 7.5 g (87%).

Provenance & Evidence