反应详情

To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.61 ethanol is added 11.0 g of 5% Pd/C. The mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i. When hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which was used without weighing in the next step.

1. customis reduced at room temperature under a hydrogen
2. filtrationWhen hydrogen uptake ceases, the catalyst is filtered off
3. concentrationthe filtrate is concentrated in vacuo