HCID 54219844, compound → HCID 22456975, compound

Participants

Reaction Conditions

Reaction Steps

3-Fluoro-4-methoxy-α-methylcinnamic acid (49.5 g; 0.236 mol), in 800 ml methanol is hydrogenated at 43 lbs. pressure and room temperature until the theoretical uptake of hydrogen has occurred (24 min at 20° C., using 1.5 g platinum oxide catalyst). The solution is filtered and then evaporated with warming to 60° C. to give 3-fluoro-4-methoxy-α-methyl dihydrocinnamic acid Rf 0.5 on silica-gel G with methylene chloride-methanol (9:1).

Provenance & Evidence