HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | 4-Chloro-alpha-methylstyrene | HCID 74381 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzoic acid, 4-(1-methylethenyl)-, methyl ester | HCID 11275336 | — |
Reaction Steps
Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998481 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-0c66f3c754bd40ea943d24950051c2a9 |
| Source note | uspto-grants-1999_12 |