反应详情

To a solution of 1-[(4-methoxy)phenyl]-3-[E-2-(methoxycarbonyl) ethenyl]-1H-pyrazole-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl) carboxyamide (35 mg, 0.065 mmol) in 20 mL of absolute ethanol at ambient temperature was added 10% palladium on carbon catalyst (3.5 mg). This mixture was stirred under 1 atm of hydrogen gas for 3 h and then was filtered through a pad of celite and concentrated in vacuo. The residue was purified by prep HPLC (C18 reverse phase column, elution with a H2O/CH3CN gradient with 0.5% TFA) and lyophilized to afford 15 mg (42%) of the title compound as a white powder. LRMS (ES+): 534.9 (M+H)+.

1. filtrationwas filtered through a pad of celite
2. concentrationconcentrated in vacuo
3. customThe residue was purified by prep HPLC (
4. washC18 reverse phase column, elution with a H2O/CH3CN gradient with 0.5% TFA) and