5-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(3-fluorophenyl)-2-methylthiazol-4-yl)methanone

HRID 61035Notes

Reaction equation

HRID 61035 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[F:25][C:26]1[CH:27]=[C:28]([C:32]2[S:36][C:35]([CH3:37])=[N:34][C:33]=2[C:38]([OH:40])=O)[CH:29]=[CH:30][CH:31]=1>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:38]([C:33]1[N:34]=[C:35]([CH3:37])[S:36][C:32]=1[C:28]1[CH:29]=[CH:30][CH:31]=[C:26]([F:25])[CH:27]=1)=[O:40]

Participants

3

Reactant 2

HCID 574371745-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727785((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(3-fluorophenyl)-2-methylthiazol-4-yl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 5-(3-fluorophenyl)-2-methylthiazole-4-carboxylic acid. MS (ESI) 348 (M+H).

Sources & evidence

ORD record
ord-a659b408775443999156e6a6cc49c502
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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