HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 610352Generated: October 25, 2026
3-Pyridinecarboxaldehyde → 6-Methoxy-3-(3-pyridyl)methylene-4-chromanone
https://huagongshe.com/reaction/610352
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-methoxy-3,4-dihydro-2H-1-benzopyran-4-one | HCID 4612168 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methoxy-3-(3-pyridyl)methylene-4-chromanone | HCID 53813079 | 57% |
Reaction Steps
To a 25° C. mixture of 20.0 g (0.112 mol) of 6-methoxy-4-chromanone and 18.09 g (0.169 mol) of 3-pyridinecarbaldehyde in 100 ml of methanol was added 14.1 ml (0.169 mol) of pyrrolidine. The resultant solution was allowed to stir 60 hours at 25° C., cooled to 0° C. and filtered to yield 17.07 g (57%) of the title compound, m.p. 127-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05998451 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-3b31463d8e9144f8a714605beb63170c |
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| Source note | uspto-grants-1999_12 |
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