Phenol → HCID 19600830, compound

HRID 610359Notes

Reaction equation

HRID 610359 reaction equation
C1(O)C=CC=CC=1.[OH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14][CH3:15])=[O:13].[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[O:36][CH2:35][CH2:34][CH:33](Br)[C:32](=[O:38])[C:31]=2[CH:39]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[O:36][CH2:35][CH2:34][CH:33]([O:8][C:9]3[CH:18]=[CH:17][CH:16]=[C:11]([C:12]([O:14][CH3:15])=[O:13])[CH:10]=3)[C:32](=[O:38])[C:31]=2[CH:39]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 88068Methyl 3-HydroxybenzoateHCID 14422726HCID 14422726, compound

Product 1

HCID 19600830HCID 19600830, compound

Procedure

By the method of Example 27, substituting the phenol with a molar equivalent of methyl 3-hydroxybenzoate, 7-benzyloxy-4-bromo-3,4-dihydro-1-benzoxepin-5(2H)-one (17.3 g) was converted to present title product, 10.9 g, m.p. 134-136° C.

Sources & evidence

ORD record
ord-4a5d1e301a7241689fd8c909b1a042ed
Source dataset
uspto-grants-1999_12
Patent number
US05998451

Reaction notes

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