Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 6-Benzyloxy-3-(3-(methoxycarbonyl)benzylidene)-4-chromanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Methyl 3-formylbenzoate | HCID 639145 | — |
| 반응물 | 6-(Benzyloxy)chroman-4-one | HCID 14422776 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 6-Benzyloxy-3-(3-(methoxycarbonyl)benzylidene)-4-chromanone | HCID 54563585 | 64.3% |
반응 단계
A mixture of 17 g of 6-benzyloxy-4-chromanone, 11.3 g of 3-carbomethoxybenzaldehyde, 14.4 g of pyrrolidine, 100 ml of tetrahydrofuran and 300 ml of methanol was stirred at room temperature overnight. The volatiles were evaporated in vacuo to afford the crude product, which was purified by column chromatography on silica gel eluting with dichloromethane. The product fractions were combined and concentrated to an oil which crystallized upon trituration with methanol to give 17.2 g of title product, m.p. 109-112° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05998451 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-2e489223924c41aab8cf97f99903740c |
| 출처 메모 | uspto-grants-1999_12 |