HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 6-Benzyloxy-3-(1-imidazolyl)methyl-4-chromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 6-Benzyloxy-3-methylene-4-chromanone | HCID 14422790 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Benzyloxy-3-(1-imidazolyl)methyl-4-chromanone | HCID 19600626 | 64.6% |
Reaction Steps
A solution of 3.7 g of 6-benzyloxy-3-methylene-4-chromanone and 3.7 g of imidazole in 50 cc of DMF was heated at 60° C. for 1.5 hours. The reaction was allowed to cool, then poured into water and extracted with ethyl acetate. The combined organic layers were dried over Na2SO4 and evaporated to give 4 g of crude product which was purified by recrystallization from CH2Cl2 /ether to give 3 g of title product, m.p. 108-110° C. MS calculated for C20H18N2O3 : 334.1317; found: 334.1317.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998451 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-271091ac41304fef9d92c3b1c1ba5872 |
| Source note | uspto-grants-1999_12 |