HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)-6-chloro-pyridine → trans-3-Benzyl-6-(6-chloro-2-pyridyl)methoxy-4-chromanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)-6-chloro-pyridine | HCID 22032737 | — |
| Reactant | trans-3-Benzyl-4,6-chromandiol | HCID 67592272 | — |
| Product | trans-3-Benzyl-6-(6-chloro-2-pyridyl)methoxy-4-chromanol | HCID 86745188 | — |
Reaction Steps
By the method of Example 5, 0.50 g (1.96 mmol) of trans-3-benzyl-4,6-chromandiol and 445 mg (2.16 mmol) of 2-chloro-6-(bromomethyl)pyridine were converted to present title product purified by recrystallization from CH2Cl2 /hexane, to yield 0.50 g (67%) of present title compound, m.p. 117-119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998451 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-ff626d1f06414309a4b61abacb382c82 |
| Source note | uspto-grants-1999_12 |