2-(Bromomethyl)-6-methylpyridine → trans-6-(6-Methyl-2-pyridyl)methoxy-3-(3-pyridyl)methyl-4-chromanol

Participants

Reaction Steps

By the method of Example 5, 0.50 g (1.95 mmol) of trans-3-(3-pyridylmethyl)-4,6-chromandiol and 400 mg (2.15 mmol) of 2-(bromomethyl)-6-methyl pyridine were converted to present title product, purified by flash chromatography on silica gel using ethyl acetate as eluant to yield purified title product, 0.14 g (20%), m.p. 66-68° C.

Provenance & Evidence