Picolyl chloride → trans-6-(2-Pyridyl)methoxy-3-(3-pyridyl)methyl-4-chromanol

Participants

Reaction Steps

By the method of Example 5, 500 mg (1.95 mmol) of trans-3-(3-pyridyl methyl)-4,6-chromandiol and 266 mg (2.09 mmol) of 2-picolyl chloride were converted to present title product, purified by flash chromatography on 100 g silica gel using 1:19 CH3OH:ether as eluant to yield 136 mg (20%) of present title compound as an oil.

Provenance & Evidence