2-Methylpyridin-3-ol → HCID 19991522, compound

HRID 610383Notes

Reaction equation

HRID 610383 reaction equation
[CH3:1]C1C(O)=CC=CN=1.[CH2:9]([O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[O:23][CH2:22][CH:21]([O:27][C:28]1[C:29](C)=[N:30][CH:31]=[CH:32][CH:33]=1)[C:20]2=[O:35])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)(Cl)Cl>[CH2:9]([O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[O:23][CH2:22][CH:21]([O:27][C:28]1[CH:29]=[N:30][C:31]([CH3:1])=[CH:32][CH:33]=1)[C:20]2=[O:35])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 707192-Methylpyridin-3-olHCID 19091476HCID 19091476, compound

Product 1

HCID 19991522HCID 19991522, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

By the same methods, 2-methyl-3-hydroxypyridine (7.30 g, 0.067 mol) was converted to 1.17 g of 6-benzyloxy-3- (2-methyl-3-pyridyloxy) -4-chromanone [1H-NMR includes delta 2.48 (s, 3 H), 4.6 (m, 2 H) and 4.93 (dd, 1 H); MS includes 361 (M+) and base peak at 91; IR (CHCl3) 1697, 1486 cm-1 ].

Sources & evidence

ORD record
ord-84ab2239b7b2426e847b8f4a0dbf557f
Source dataset
uspto-grants-1999_12
Patent number
US05998451

Reaction notes

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