HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 610389Generated: November 1, 2026
Gamma-Butyrolactone → 4-(4-Methoxyphenoxy)butanoic acid
https://huagongshe.com/reaction/610389
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Gamma-Butyrolactone | HCID 7302 | — |
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Methoxyphenoxy)butanoic acid | HCID 249649 | — |
Reaction Steps
4-Methoxyphenol was added to a solution of NaOC2H5 made by dissolving 2.3 g of Ka in 50 ml ethanol. After 5 minutes, gamma-butyrolactone was added and the mixture heated at reflux overnight. Ethanol was distilled off and the residue heated at 155° C. overnight, then cooled, diluted with water and acidified to pH 3 with dilute hydrochloric acid. The product was collected by filtration, 19.5 g, m.p. 103-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05998451 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-c19334e6556e4c52bfd69ba97c29e7a3 |
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| Source note | uspto-grants-1999_12 |
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