Isovaleryl chloride → 5-(N-[3-methylbutanoyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

HRID 610498Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 610498
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[CH3:18][CH:19]([CH3:24])[CH2:20][C:21](Cl)=[O:22]>>[CH3:18][CH:19]([CH3:24])[CH2:20][C:21]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)=[O:22]

Komponenten

3

Edukt 2

HCID 66054Isovaleryl chlorideHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Produkt 1

HCID 196014925-(N-[3-methylbutanoyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridineAusbeute 60 %

Versuchsvorschrift

Beginning with 0.010 gm (0.044 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.048 mMol 3-methylbutanoyl chloride, 0.008 gm (60%) of the title compound were prepared essentially by the procedure described in Example 7.

Quellen und Nachweise

ORD-Eintrag
ord-6f4fac0340ad4b87ac9d5f4dfec620ad
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998622

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