HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromothiophene-2-carbonyl chloride → 5-(N-[3-bromo-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromothiophene-2-carbonyl chloride | HCID 2797569 | — |
| Reactant | 3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine | HCID 10220230 | — |
| Product | 5-(N-[3-bromo-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine | HCID 19601495 | 49.2% |
Reaction Steps
Beginning with 0.37 gm (1.6 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.45 gm (2.0 mMol) 3-bromo-2-thiophenecarbonyl chloride, 0.33 gm (49%) of the title compound were prepared essentially by the procedure described in Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998622 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-5236e26aaf7b4b23a9a349659b26ce73 |
| Source note | uspto-grants-1999_12 |